Ace inhibitors in the treatment of arterial hypertension (literature review)

Literature data on the role of renin-angiotensin-aldosterone system in pathogenesis arterial hypertension and angiotensin-converting enzyme inhibitors treatment have been given.The is central element controlling body's water-salt balance blood pressure. The main effector link renin-angiotensin angiotensin II, which causes vasospasm, activates heart contraction, inhibits production bradykinin, promotes proliferation, fibrosis vessels myocardium, synthesis aldosterone glomerular zone adrenal cortex.Angiotensin-converting are mainstay hypertension. They contribute to correction hypertension, hypertrophy, remodeling left ventricle, endothelial dysfunction, proliferation smooth muscles, thrombotic phenomena. 2018 ESH/ESC guidelines state that first-line therapy most patients with should be a fixed combination blocker calcium channel or diuretic. Blockade currently considered gold standard antihypertensive therapy.The objective systematize modern literature ACE Conclusion. To date, concept (RAАS) has formulated.